A comprehensive assay for biomarker discovery in plasma

PGDx elio™ plasma complete* analyzes circulating tumor DNA for genetic alterations in cancer, eliminating the need for an invasive biopsy or tumor tissue. PGDx elio plasma complete* evaluates a comprehensive panel of 521 genes. Cell-free DNA (cfDNA) is extracted from plasma and prepared using proprietary methods that accommodate low abundance sample DNA. Samples are processed using a proprietary capture process and high coverage next-generation sequencing. Designed to be used across the globe on the PGDx elio™ testing platform, PGDx elio plasma complete* also includes automated bioinformatics ensuring consistent, high-quality results. With deep coverage, this assay identifies somatic mutations within cfDNA with high accuracy and sensitivity, providing information on single nucleotide variants, insertions/deletions (indels), amplifications, translocations, loss of heterozygosity (LOH), microsatellite instability (MSI) status, and tumor mutation burden (TMB).

*For Research Use Only

  • Plasma analysis for pan-cancer solid tumor biomarker testing and discovery
  • 500+ gene kitted assay developed under Design Control
  • Comprehensive coverage of biomarkers, clinically relevant targets, cancer signaling pathways and DNA damage repair pathways
  • Large panel size supports TMB and LOH

Benefits of Using PGDx elio plasma complete

END-TO-END KITTED SOLUTION

DETECTS MICROSATELLITE INSTABILITY (MSI),
LOSS OF HETEROZYGOSITY (LOH),
TUMOR MUTATION BURDEN (TMB),
COMPLEX STRUCTURAL ALTERATIONS AND AMPLIFICATIONS

IDENTIFIES MANY
CLINICALLY RELEVANT TARGETS
FROM A SINGLE SAMPLE

DEVELOPED UNDER
DESIGN CONTROL TO MEET
REGULATORY STANDARDS

UTILIZES ROBUST TURN-KEY
BIOINFORMATICS PIPELINE
TO KEEP DATA AND RESULT
REPORTING IN-HOUSE

Key Metrics

500+ 500+ Full Coding Genes For Sequence Mutations
7-8 Days 7-8 Days Turn-Around Time
25,000X 25,000x Sequencing Coverage
Somatic Variants Somatic Variants SNVs, Indels, Amplifications and Translocations
LOH, TMB & MSI LOH, MSI, TMB Proprietary Calling Methods
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