A liquid biopsy for pan-cancer genomic analysis

PGDx elio™ plasma resolve* analyzes circulating tumor DNA for genetic alterations in cancer, eliminating the need for an invasive biopsy or tumor tissue. PGDx elio plasma resolve* may also be used to evaluate sub-clonal mutations in tumor tissue, when available. PGDx elio plasma resolve* evaluates a targeted panel of 33 well-characterized cancer genes. Cell-free DNA is extracted from plasma and prepared using proprietary methods that accommodate low abundance sample DNA. Samples are processed using a proprietary capture process and high coverage next-generation sequencing to allow tumor-specific (somatic) mutations, microsatellite instability (MSI) and translocations to be identified with a high sensitivity and specificity. Analyses for sequence mutations or rearrangements can be performed together or separately, depending on the specific alterations of interest.

*For research use only

  • Identifies variants in 33 Full Coding Genes across multiple cancer types
  • Detects SNVs, Indels, Amplifications, Translocations & MSI
  • 4-5 day turn-around time
  • Automated bioinformatics and results generation

Benefits of Using PGDx elio plasma resolve

END-TO-END
KITTED SOLUTION

DETECTS MICROSATELLITE
INSTABILITY (MSI), COMPLEX
STRUCTURAL ALTERATIONS
AND AMPLIFICATIONS

IDENTIFIES MANY
CLINICALLY RELEVANT
TARGETS FROM A SINGLE
SAMPLE

DEVELOPED UNDER DESIGN
CONTROL TO MEET
REGULATORY STANDARDS

UTILIZES ROBUST TURN-KEY
BIOINFORMATICS PIPELINE
TO KEEP DATA AND RESULT REPORTING IN-HOUSE

 

Gene Panel

SEQUENCE MUTATION ANALYSIS (33 GENES)

AKT1 BRAF CD274 EZH2 KRAS PDGFRA RET  
ALK BRCA1 CDH1 FGFR1 MET PIK3CA ROS1  
APC BRCA2 CSF1R FGFR2 MYC POLD1 TP53  
ARID1A BRIP1 EGFR HRAS NRAS POLE    
ATM CCND1 ERBB2 KIT NTRK1 RAF1    

COPY NUMBER VARIATION (8 GENES)

CCND1 MYC CD274 FGFR2 EGFR ERBB2 KIT MET

TRANSLOCATIONS (5 GENES)

ALK FGFR2 NTRK1 RET ROS1      

 

 

 

Key Metrics

33+ Full Coding Genes For Sequence Mutations
4-5 Days Turn-Around Time
30,000xSequencing Coverage
Somatic Variants SNVs, Indels, Amplifications, and Translocations
MSI Proprietary Calling Methods
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