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With the Nobel Prizes around the corner, it’s crystal ball time

Really, we at STAT love autophagy, the cell’s garbage disposal. Also those adorable little molecular machines. Discoveries about the former won the Nobel Prize in medicine last year for Yoshinori Ohsumi, while three inventors of the latter won the chemistry prize. But if Bob Dylan can win the literature Nobel, can science Nobels go to…

‘Epigenetic’ Changes From Cigarette Smoke May be First Step in Lung Cancer Development

Newswise — Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory-grown, human airway cells that a condensed form of cigarette smoke triggers so-called “epigenetic” changes in the cells consistent with the earliest steps toward lung cancer development.Epigenetic processes are essentially switches that control a gene’s potentially…

Sequencing of Circulating Tumor DNA Detects Early Cancers

For their proof-of-principle analysis, published online today in Science Translational Medicine, the researchers did liquid biopsies on 200 individuals with colorectal, breast, lung, or ovarian cancer, and nearly four dozen healthy controls, using an ultra-deep sequencing approach known as targeted error correction sequencing (TEC-Seq) to assess a panel of 58 cancer-related genes in circulating, cell-free DNA.“The…