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    PROGENEUSTM

    NGS kit & bioinformatic software for molecular laboratories

    Read More For Research Use Only
    Not for Clinical Diagnostic Purposes
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    PROGENEUSTM

    Your PROGENEUSTM for NGS testing

    Read More For Research Use Only
    Not for Clinical Diagnostic Purposes
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    PROGENEUSTM

    Proprietary technology for examining cancer

    Read More For Research Use Only
    Not for Clinical Diagnostic Purposes
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What is PROGENEUSTM?

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Next-generation sequencing solution

PROGENEUSTM facilitates the process to rapidly build a high quality testing solution by packaging a comprehensive suite of cancer NGS components in tissue and plasma.

This solution is ideal for labs that

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ASPIRE TO RUN HIGH-QUALITY NGS TESTING WITH MINIMAL R&D, BIOINFORMATICS OR LABORATORY INVESTMENT
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WANT TO INTERROGATE THE MOST IMPORTANT GENES FOR SEQUENCE MUTATIONS, AMPLIFICATIONS, GENOMIC REARRANGEMENTS, AND MICRO-SATELLITE INSTABILITY

Testing Workflow

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Set up your lab

PGDX WILL HELP YOU GET STARTED WITH YOUR LAB IN AS LITTLE AS 12 WEEKS INCLUDING RAPID SET-UP AT YOUR SITE, CUSTOMIZED TRAINING, AND VERIFICATION SUPPORT.

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Step 1: INFRASTRUCTURE

An onsite server houses VariantDx™ to provide automated data analysis while insuring the security of valuable sample data from Illumina MiSeq or HiSeq platforms. Optional storage pods can be obtained from PGDx to store raw sequencing data.

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Step 2: TRAINING

Following equipment orders (if necessary), PGDx will provide customized training for your molecular laboratory to run high quality NGS cancer testing.

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Step 3: VERIFICATION SUPPORT

Optional samples of well characterized mutations in both FFPE and ctDNA formats are available for verification purposes.

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run your test

UPON LAUNCHING YOUR TEST, YOUR LABORATORY WILL BE ABLE TO OFFER COMPREHENSIVE NGS TESTING FOR LARGE PANELS OF CANCER GENES WITH A 1-2 WEEK TURN-AROUND TIME.

  • Step 1: Sample Prep and Sequencing

    Your laboratory prepares and sequences a sample using PROGENEUS™ capture probes and the validated proprietary PGDx methods.

  • Step 2: DATA Analysis

    PGDx securely and remotely analyzes, visually inspects and curates results for the raw sequence data. If the data does not meet acceptance criteria, PGDx will alert your lab. VariantDx is the only bioinformatics pipeline validated and optimized against hundreds of millions of Sanger sequenced matched tumor/ normal base pair calls and over 10,000 fusion events-delivering the lowest false positive rate and most accurate germline filter of any commercially available NGS cancer testing variant calling software.

  • Step 3: REPORTING TUMOR SPECIFIC ALTERATIONS

    PGDx provides sequencing data and analysis integration for customized reporting. Available in flexible data formats (using XML or tab-delimited formats) for easy integration with your laboratory information system (LIS). Optional clinical annotation services including clinical trials and drug therapies are available.

  • Step 4: LIVE TECHNICAL SUPPORT

    PGDx is available by phone or email, connecting you to experts that can assist across every stage of the laboratory and data analysis workflow.

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what is included?

  • Operating procedures

    Set of standard operating procedures optimized for running NGS testing using VariantDx. Validation samples to run in your lab (optional).

  • REAGENT KITS

    All the key reagents required to prepare genomic libraries for sequencing from extracted DNA on Illumina’s MiSeq and HiSeq NGS platforms.

  • PGDx BioInformatics Software

    Use of proprietary PGDx bioinformatics software, VariantDx :

    • Detects sequence mutations, amplifications, and genomics rearrangements.
    • Uses dataset of unmatched size and quality to develop and fine-tune proprietary analysis tools and algorithms.
    • Complementary, multi-aligner approach.
    • Finely tuned scoring and filtering algorithms.
    • Visual inspection by cancer genome experts (optional).

  • Customized Training

    Hands-on training at the PGDx laboratory or onsite at your lab with continual web based training.

  • FLEXIBLE DATA FORMATS

    Customizable electronic result files with the list of tumor-specific genetic variants identified with clinical annotation (optional).

Advantages

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Expedited Timing

A validated molecular laboratory can launch the PROGENEUSTM program in as little as 12 weeks and offer 1-2 week testing turn-around time.

Minimize Cost

• Minimal up-front costs while leveraging Illumina’s HiSeq® and MiSeq® platforms

• No ongoing costs to maintain and update the analysis pipeline and NGS testing panel

Develop & Maintain High Quality NGS Testing

• Access to state-of-the-art NGS testing and analysis pipelines

• Optimized test design for greater accuracy

• Dedicated technical support and access to expert resources

For Research Use Only. Not for use in diagnostic procedures.

Contact us

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We love questions & comments

Contact us to learn more